An Analysis on Size-limitation of Swine Myocardial Infarction with A Reference to Effects of Saiko-ka-ryukotsu-borei-to.
10.3937/kampomed.52.483
- VernacularTitle:虚血性心疾患と漢方方剤に関する研究 ＩＩ 柴胡加竜骨牡蛎湯の心筋梗塞巣制限化についての検討
- Author:
Tsutomu YAMADA
;
Toshinori OINUMA
;
Makoto YOSHIMURA
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
size-limitation;
coronary artery;
cineangiography;
Saiko-ka-ryukotsu-borei-to;
swine
- From:Kampo Medicine
2002;52(4-5):483-492
- CountryJapan
- Language:Japanese
-
Abstract:
We studied the effect of Kampo for the size-limitation of myocardial infarct with morphometrical analysis, utilizing total of 19 male swine. A hand made metal-coil (2×1mm) was inserted in the left anterior descending coronary artery (LAD) of swine with catheterization, in order to induce acute myocardial infarction (AMI). After occurrence of AMI, the swine were divided into two groups, experimental group: Saiko-ka-ryukotsu-borei-to (n=10) and control (n=9). This Kampo formula (0.66/kg/day) was administered via stomach tubes for 4 weeks. The control group received basal rations alone. After serial cross sections of heart, total infarct areas were weighed.
An infarct weight to heart weight of the experimental group (2.9±1.6%, n=10) was significantly decreased than that of the control group (8.2±4.8%, n=9). The infarct weight to left ventricular weight of the experimental group (4.9±2.6%) was significantly decreased than that of the control group (13.4±8.0%). Thus the infarct size of the experimental group was significantly smaller than that of the control. The histological character of the infarct in the control was numerous inflammatory cell infiltration and foci of fresh coagulate necrosis in the border zone, while the infarct of the experimental group was apparent in the border zone with marked fibrosis and few inflammatory cells. Angiogenesis in both the infarct and border zone was marked in the experimental group than in the control. We summarize that this Kampo formula inhibits size development of AMI in animal model.
