Effects of Juzen-taiho-to and M-CSF on Thrombocytopenia induced by Anti-cancer Drugs in Gynecologic Malignancies.
10.3937/kampomed.51.447
- VernacularTitle:婦人科癌症例における抗癌化学療法後の血小板減少症に対する十全大補湯とＭ‐ＣＳＦ併用療法の有用性
- Author:
Kenji NIWA
;
Midori HASHIMOTO
;
Teruhiko TAMAYA
- Publication Type:Journal Article
- Keywords:
Anti-cancer chemotherapy;
Thrombocytopenia;
Juzen-taiho-to;
M-CSF;
TGF-β1
- From:Kampo Medicine
2000;51(3):447-454
- CountryJapan
- Language:Japanese
-
Abstract:
We investigated the clinical effect of Juzen-taiho-to and macrophage-colony stimulating factor (M-CSF) on thrombocytopenia induced by anti-cancer chemotherapy in gynecologic malignancies. We discussed 31 courses in 20 patients. Juzen-taiho-to and/or M-CSF were given when indicated from serum platelet level. Twenty-eight courses (90.3%) in 17 patients did not need transfusion of platelet, and 3 courses in 3 patients needed it. It suggested that Juzen-taiho-to and M-CSF might be effective. As platelet-free plasma TGF-β1 level during the treatment of Juzen-taiho-to alone was remarkably increased, it might enhance the antitumoral action. Accordingly, combination treatments of Juzen-taiho-to and M-CSF might be effective for thrombocytopenia induced by anti-cancer chemotherapy.
