A Case of Hepatitis and Interstitial Pneumonitis Induced by Hangeshashin-to and Shosaiko-to.
10.3937/kampomed.50.57
- VernacularTitle:半夏しゃ心湯，小柴胡湯により薬剤性肝障害ならびに間質性肺炎を来した一例
- Author:
Yumi OKADA
;
Kenji WATANABE
;
Yukio SUZUKI
;
Kunihiko SUZUKI
;
Go ITO
;
Akihiko MURANUSHI
;
Shigeru KURAMOCHI
;
Kanji TSUCHIMOTO
;
Shogo ISHINO
;
Toshihiko HANAWA
- Publication Type:Journal Article
- Keywords:
Hangeshashin-to;
Shosaiko-to;
interstitial pneumonitis;
liver dysfunction;
Th1/Th2 balance
- From:Kampo Medicine
1999;50(1):57-65
- CountryJapan
- Language:Japanese
-
Abstract:
A 60-year-old male patient visited the Oriental Medicine Research Institute of the Kitasato on ***** because of abdominal discomfort. Hangeshashin-to was administered to him and the abdominal discomfort was relieved. He continued to take Hangeshashin-to from June to August 1997. He had chills, high fever, and fatigue from ********. He stopped Hangeshashin-to and took Shosaiko-to for five days because of liver dysfunction. He was admitted to our hospital on ********. Antibiotics and stronger neo-minophagen C were administered to him. A chest roentgenogram revealed a ground-glass shadow on the left upper lung, and Shosaiko-to was discontinued. The patient began to complain of dyspnea and had fine crackles on the chest. A chest roentgenogram and chest CT showed interstitial pneumonitis. Oral predonisolone therapy was started for hypoxemia and the patient improved. A drug lymphocytes stimulation test revealed that lymphocytes were stimulated by Shosaiko-to and its components, Saiko and Ogon. A chest roentgenogram just before ingesting Hangeshashin-to revealed the interstitial change of the lung. Taken all together, this patient suffered from druginduced hepatitis and pneumonitis as a result of ingesting Hangeshashin-to and Shosaiko-to.
