The Effect of Kampo Medicine in Rats with Adjuvant Arthritis; The Effect of Sokei-kakketsu-to and Yokuinin-to on Serum Dipeptidyl Aminopeptidase IV.
10.3937/kampomed.49.805
- VernacularTitle:ラット・アジュバント関節炎における漢方薬の作用 血清Ｄｉｐｅｐｔｉｄｙｌ Ａｍｉｎｏｐｅｐｔｉｄａｓｅ ＩＶの変化に対する疎経活血湯，よくい仁湯の作用 第３報
- Author:
Fang TANG
;
Yuka NAKANISHI
;
Machiko ORITA
;
Hiroko ABE
- Publication Type:Journal Article
- Keywords:
adjuvant arthritis;
rat;
serum dipeptidyl aminopeptidase (DAP IV);
steroid;
Sokei-kakketsu-to;
Yokuinin-to
- From:Kampo Medicine
1999;49(5):805-815
- CountryJapan
- Language:Japanese
-
Abstract:
Rats with adjuvant arthritis (AA rats) show obvious inhibition of the local inflammation when steroids (DXM) are administered. But the contraction of thymic or adrenal atrophy, spleen hypertrophy, and reduction of activity of serum dipeptidyl aminopeptidase IV are recognized. In rats where Sokei-kakketsu-to or Yokuinin-to was administered, prominent anti-inflammatory effects like dexamethasone were not found; however the contraction of thymic or adrenal atrophy, spleen hypertrophy, and reduction of activity of serum dipeptidyl aminopeptidase IV was not recognized. In addition, after withdrawal of drugs, rebound in regional joints did not occurr as with steroids, and the reducing effect for arthrocele was prolonged. Therefore, it was concluded that those two formulations have an effect on the immune system —with anti-inflammatory effects for AA rats— and these action mechanisms are different from that of steroids (DXM).
