Hematological Change in the Adjuvant-Induced Arthritis of Rats (II). Effects of Kampo Medicine Extracts on the Inflammatory Index Substances and Platelet.
10.3937/kampomed.49.597
- VernacularTitle:ラット・アジュバント関節炎における漢方薬の作用 （第２報） 血小板，血清炎症指標に及ぼす漢方薬の作用
- Author:
Fang TANG
;
Yuka NAKANISHI
;
Machiko ORITA
;
Hiroko ABE
- Publication Type:Journal Article
- Keywords:
adjuvant induced arthritis, rats;
sialic acid;
albumin;
Chinese medicine (Sokeikakketsu-to, Yokuinin-to, Keisi-ka-jutsubu-to, Eppi-ka-jutsu-to, Sairei-to);
ASGP
- From:Kampo Medicine
1999;49(4):597-605
- CountryJapan
- Language:Japanese
-
Abstract:
The hematological effects of Sokeikakketsu-to, Yokuinin-to, Keisi-ka-jutsubsu-to, Eppi-ka-jutsu-to, and Sairei-to observed on the AA rats were investigated. The time course of blood count and albumin, sialic acid and acid-soluble glycoprotein in the serum whs. were measured. Sokeikakketsu-to had the strongest anti-inflammatory effect on the improvement of Inflammatory Index Substances, platelets, and the Arthritis Score for changes in synovitis. Yokuinin-to was also effective. When these Kampo medicines were administered in the early stages of AA, Sokeikakketsu-to improved the AA signficantly. The results may suggest that Sokeikakketsu-to works for the control of autoimmunity. On the other hand, Keisi-ka-jutsubu-to aggravated the AA when it was administered in the early stages of the AA.
