Inhibitory Effect of Ougi-keisi-gomotu-to on oxidative stress.
10.3937/kampomed.48.177
- VernacularTitle:黄ぎ桂枝五物湯の酸化的ストレスに対する抑制効果
- Author:
Shizuo TODA
;
Yoshiro YASE
- Publication Type:Journal Article
- Keywords:
active oxygen;
hydroxy radical;
lipid peroxidation;
Ougi-keishi-gomotsu;
oxidative stress
- From:Kampo Medicine
1997;48(2):177-183
- CountryJapan
- Language:Japanese
-
Abstract:
It has been suggested that various neurological diseases (particularly those accompanying aging, the cranial nerves, etc.) involve oxidative stress. Some of these diseases have been successfully controlled with traditional herbal medicine. In the present study, Ougi-keishi-gomotsu-to, reported to be effective against subacute myelo-opticoneuropathy (SMON), showed an inhibitory effect on lipid peroxidation of homogenate by hydroxy radical, a type of active oxygen derived from the interaction of Fe3+ and 8-hydroxyquinoline. 8-hydroxyquinoline is a homologue of chinoform, which is causally related to the pathogenic process of SMON. It has also been indicated that Ougi-keishi-gomotsu-to has a hydroxy radical scavenger with radical-quenching effects. It is, therefore concluded that Ougi-keishi-gomotsu-to has an inhibitory effect on oxidative stress.
