Suppressive Effects of Kambaku-taiso-to on the Yawning Induced by Dopaminergic Agonist in Rats.
10.3937/kampomed.48.53
- VernacularTitle:ラットにおける甘麦大そう湯のドパミン作動薬誘発あくび行動に対する抑制作用
- Author:
Hiroshi KIMURA
- Publication Type:Journal Article
- Keywords:
dopaminergic agonist;
Kambaku-taiso-to (Gan mai da zao tang);
yawning;
Oriental herbal medicine
- From:Kampo Medicine
1997;48(1):53-57
- CountryJapan
- Language:Japanese
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Abstract:
The present experiments were performed to investigate the potential role of Kambaku taiso-to (Gan mai da zao tang) in modifying the occurrence of yawning in rats. Subcutaneous injection of talipexole, a selective dopamine D-2 receptor agonist, at 5-100μg/kg, elicits yawning behavior for over one hour, the maximal effect being observed at a dose of 25μg/kg. Kambaku-taiso-to significantly suppressed the incidence of yawning induced by talipexole. These results suggest that Kambaku-taiso-to exerts a suppressive effect on the incidence of yawning.
