Clinical Effectiveness of Oren-Gedoku-To for Insomnia associated with Acute Schizophrenia and Other Psychotic Disorders.
10.3937/kampomed.47.827
- VernacularTitle:精神分裂病および他の精神病性障害患者の急性期における睡眠障害に対する黄連解毒湯の臨床効果
- Author:
Kazuo YAMADA
;
Shigenobu KANBA
;
Kimio OHNISHI
;
Hiroko MIZUSHIMA
;
Chikayo UMEYAMA
;
Fumitake KATOH
;
Motoko FUKUZAWA
;
Takaaki MURATA
;
Bokusou TERASHI
;
Masahiro ASAI
- Publication Type:Journal Article
- Keywords:
Orengedoku-to;
insomnia;
schizophrenia
- From:Kampo Medicine
1997;47(5):827-831
- CountryJapan
- Language:Japanese
-
Abstract:
Eighteen untreated patients with schizophrenia and other psychotic disorders, all of whom had insomnia among their chief complaints, were randomly divided into two groups. For four weeks, nine patients (group A) were treated with neuroleptics (haloperidol) and Orengedokuto, and the remainder (group B) were treated with neuroleptics alone. Changes in schizophrenic symptoms and the number of doses of hypnotics (nitrazepam) were examined. In group A, the thought disturbance (conceptual disorganization, grandiosity, hallucinatory behavior, unusual thought content) aspect of schizophrenic symptoms improved (p=0.06), and the number of doses of hypnotics (mean=1.9) was smaller (p=0.06), as compared with group B (mean=7.7). These observations suggest that augmentation therapy with Orengedoku-to is potentially effective for the treatment of insomnia associated with schizophrenia and other psychotic disorders.
