The Effects of a Kampo Formula in Combination with Amoxicillin and Omeprazol in Eradicating Helicobacter pylori.
10.3937/kampomed.47.803
- VernacularTitle:Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉに対する漢方製剤を用いた除菌療法の検討
- Author:
Gen TOHDA
;
Teruyuki KANE
;
Chie SUZUKI
;
Shotaro KOSAKA
;
Toshiaki TAKAHASHI
;
Toshio OKUNO
;
Takeshi ISHIZAKI
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
methods of bacteria eradication;
omeprazol;
amoxicillin;
Hangeshashin-to;
Sanoshashin-to
- From:Kampo Medicine
1997;47(5):803-812
- CountryJapan
- Language:Japanese
-
Abstract:
Helicobacter pylori (HP) is associated with gastroduodenal disease. Although it has been reported that HP is highly sensitive to beta-lactams and macrolides, the efficacy of these monotherapies for eradicating HP is rather poor. Recent pharmacological studies have shown the effectiveness of combined therapy using PPI, antibiotics, and bismuth agents or metronidazole, but it has been known to lead to side effects and poor patient compliance. In Japan, mucosal protective agents are principally used for the treament of gastritis and gastric ulcers, and as previously reported, some mucosal protective agents, such as sofalcon and plaunotol, have anti-HP properties. Although they are not sufficiently effective to be used as monotherapy in the eradication of HP, in combination with antibiotics and PPI, eradication rates were elevated and side effects were uncommon.
Chinese medicinal formulas have been used for stomach disease in traditional Oriental medicine. The authors studied the effects of combined therapy with Omeprazole (OPZ), AMPC and Chinese medicine (Hangeshashin-to and Sanoshashin-to) instead of mucosal protective agents in the eradication of HP. The study was conducted on a total of 137 HP positive patients with endoscopic evidence of ulcers or gastritis. Dual therapy with OPZ and AMPC had a weak eradicating effect on HP (75%), but combined therapy using OPZ, AMPC and a Chinese medical formula was successful in eradicating HP in 20 out of 24 patients (85%).
The antibacterial effects of pharmaceutical preparations and crude drug extracts of Chinese medicine against HP were examined in an in vitro study. No antibacterial action against HP was demonstrated by these agents at concentrations of less than 2000μg/ml concentration. Chinese medicinal preparations should be used in combined therapy with antibiotics and PPI for optimum efficacy in eradicating HP.
This new eradication regimen including OPZ, AMPC and Hangeshashin-to is well tolerated; side effects are minimal and uncommon. This triple therapy may be useful in the treatment of HP infection, and is referred to as a “new Japanese regimen.”
