The Effects of Choto-San (Diao-Teng-San) on Blood Pressure and Narrowing of the Retinal Arterioles in SHR and SHRSP.
10.3937/kampomed.47.13
- VernacularTitle:釣藤散のラットにおける血圧および眼底への影響について
- Author:
Masatoshi MURATA
;
Shigeki TAKAHASHI
- Publication Type:Journal Article
- Keywords:
Choto-san (diao teng san);
retinal arterioles;
spontaneously hypertensive rats (SHR)
- From:Kampo Medicine
1996;47(1):13-16
- CountryJapan
- Language:Japanese
-
Abstract:
It has been reported that Choto-san (diao teng san) is effective for the treatment of patients suffering from hypertension. Narrowing of the retinal arterioles is one of the important findings in hypertension.
The authors examined the pharmacological effects of Choto-san on the blood pressure and narrowing of the retinal arterioles in spontaneously hypertensive rats (SHR) and strokeprone SHR (SHRSP).
SHR and SHRSP rats (nine treatment cases and five control cases) were used. 200mg/kg/day of Choto-san was administered orally to the SHR and SHRSP for 12 weeks. After the 12 weeks of administration, the blood pressure was measured by the tailcuff method. Narrowing of the retinal arterioles was measured by the percentage ratio of the artery to vein caliber.
After three months of administration of Choto-san, the blood pressure of the SHR and SHRSP was shown to be significantly lower than that of the control. The percentage ratio of the artery to vein caliber in the treatment group was shown to be significantly higher than that of the control group SHR and SHRSP.
These findings suggest that Choto-san may lower the blood pressure and inhibit narrowing of the retinal arterioles in SHR and SHRSP.
