The Effectiveness of Shakuyaku-kanzo-to on Myotonia in a Case of Myotonic Dystrophy.
10.3937/kampomed.46.773
- VernacularTitle:筋緊張性ジストロフィー症のミオトニーにしゃく楽甘草湯が有効であった一例
- Author:
Yoshikazu MASUI
;
Nakaaki OHSAWA
;
Hideto NAKAJIMA
;
Mami YOSHIDA
;
Tomonori SHIBUYA
- Publication Type:Journal Article
- Keywords:
myotonic dystrophy;
myotonia;
Shakuyaku-kanzo-to;
glycyrrhizin;
K-ion-channel of muscle membrane
- From:Kampo Medicine
1996;46(5):773-778
- CountryJapan
- Language:Japanese
-
Abstract:
The effectiveness of Shakuyaku-kanzo-to on myotonia in a 50-year-old female with myotonic dystrophy is reported. Neurological examination showed myogenic distal dominant muscle weakness and myotonia. Treatment with Shakuyaku-kanzo-to improved myotonic time from 12.8 to 6.8 seconds. This effect was equal to phenytoin and mexiletine. The results indicated that Shakuyaku-kanzo-to affected the ion channels of the skeletal muscle membrane. The apaminsensitive K channel was speculated to be the affected site of the ion channel. Glycyrrhizin might play an important role in this mechanism.
Five week treatment with Shakuyaku-kanzo-to showed no adverse effects on the myopathy.
