The Effects of Byakko-ka-ninjin-to on Patients in whom Thirst has been induced by Disopyramide Phosphate.
10.3937/kampomed.46.433
- VernacularTitle:ジソピラミドにより生じる口渇に対する白虎加人参湯エキス細粒の使用経験
- Author:
Shuji YAKUBO
;
Koichi KOMAKI
- Publication Type:Journal Article
- Keywords:
Disopyramide;
thirst;
Byakko-ka-ninjin-to
- From:Kampo Medicine
1995;46(3):433-438
- CountryJapan
- Language:Japanese
-
Abstract:
Disopyramide phosphate, administered to treat arrhythmias, has an anti -cholinergic effect and produces thirst. As the herbal preparation Byakko-ka-ninjin-to is known to ameliorate the symptom of thirst, Kanebo Byakko-ka-ninjin-to extract was administered orally at a dose of 6.0g/day for 12 weeks. Its efficacy was monitored in the 11 patients receiving this treatment for thirst resulting from Disopyramide phosphate in the form of time-release tablets.
No adverse influence on the effectiveness of the Disopyramide phosphate in the treatment of arrythmias was observed upon administration of this Kampo formula. No side effects were observed in 81.8% of the cases. “Remarkable improvement” in thirst was reported by 18.2% of the cases, “improvement” was described by 27.3%, “slight improvement” was presented by 18.2% and “no remarkable change” was experienced by 18.2%. No cases (0%) had “worsening” and no evaluation was possible in 18.2% of the cases. The overall efficacy, which included cases in which the Kampo formula was considered “slightly effective” or better, and which also included the safety of the formula, was 63.6%.
This study suggested that Byakko-ka-ninjin-to is useful in the amelioration of the symptom of thirst, a common side-effect of Disopyramide phosphate.
