Statistical Aproach with a two dimensional power-normal transformation model to the circadian rhythm of blood pressure. Application to a clinical phase-one study of a Kampo formulation.
10.3937/kampomed.45.509
- Author:
Akifumi YAFUNE
;
Jong-Chol CYONG
- Publication Type:Journal Article
- Keywords:
Akaike Information Criterion (AIC);
Box-Cox transformation;
circadian rhythm;
power-normal transformation;
truncated distribution
- From:Kampo Medicine
1995;45(3):509-519
- CountryJapan
- Language:English
-
Abstract:
The purpose of this paper is to propose a two dimensional power-normal transformation model to detect the circadian rhythm of blood pressure. Our model is an extension of that proposed by Uragari et al In the proposed model, we consider the correlation between systolic and diastolic blood pressures, and check the influence of the truncated data distribution after the Box-Cox transformation. An application is given to the data obtained from a clinical phase-one study of a Kampo formulation. We also discuss the necessity of evaluating the effects of Kampo formulations on the circadian rhythm of blood pressure.
