Differences between the Effects of Sho-saiko-to, Gorei-san and Toki-shakuyaku-san on the Sphincter of Oddi. An intraoperative cholangiomanometric study.
10.3937/kampomed.43.395
- VernacularTitle:Ｏｄｄｉ括約筋に対する小柴胡湯・五苓散・当帰しゃく薬散の作用の相違 術中胆道内圧測定による研究
- Author:
Masatake SEKI
;
Masashi FUJIOKA
;
Takashi HATANO
;
Hiroshi IKEDA
- Publication Type:Journal Article
- Keywords:
Cholangiomanometry;
Gallstone disease;
Sphincter of Oddi;
Sho-saiko-to (Xiao-Chai-Hu-Tang);
Gorei-san (Wu-Ling-San);
Toki-shakuyaku-san (Dang-Gui-Shao-Yao- San)
- From:Kampo Medicine
1993;43(3):395-402
- CountryJapan
- Language:Japanese
-
Abstract:
Female patients suffering from gallbladder stone disease were administered Sho-saiko-to (Xiao-Chai-Hu-Tang), Gorei-san (Wu-Ling-San) or Toki-shakuyaku-san (Dang-Gui-Shao-Yao-San) preoperatively, and were examined by cholangiomanometry during operation. Perfusion pressure was significantly elevated, when Sho-saiko-to or Gorei-san were administered, meaning that the pressure threshold of the sphincter of Oddi for volume load in the bile duct was lowered. This phenomenon tended to be more obvious in Gorei-san group, and will prevent duodenal fluid from transpapillary reflux. Parameters concerning the declining curve (T1/2, T1/4, T1/5) showed a significantly rapid relaxation of the sphincter of Oddi only in Sho-saiko-to group, which will result in a prevention of stasis of bile. These modulating functions of Sho-saiko-to and Gorei-san for the sphincter of Oddi would be one of the main reasons why these formulas are used for hypochondriac fullness and distress or excessively accumulated intestinal fluid. Toki-shakuyaku-san showed no such effects on the sphincter of Oddi.
