Pharmacokinetics of Ephedrine after Oral Administration of Sho-seiryu-to. Analysis in healthy subjects.
10.3937/kampomed.43.275
- VernacularTitle:小青竜湯投与後の血中エフェドリン動態 健康被験者における解析
- Author:
Akifumi YAFUNE
;
Jong-Chol CYONG
- Publication Type:Journal Article
- Keywords:
Sho-seiryu-to;
ephedrae herba;
ephedrine;
Akaike Information Criterion (AIC);
Monte Carlo method;
population pharmacokinetics
- From:Kampo Medicine
1992;43(2):275-283
- CountryJapan
- Language:Japanese
-
Abstract:
It is well known that there exist inter-individual variations in the pharmacokinetics of pharmaceutical components in Kampo prescriptions. In the area of Kampo medicine, however, there have so far been no reports on the analysis by introducing these variations.
In this paper, from the perspective of population pharmacokinetics, we analyze the data of plasma concentration of ephedrine obtained from 8 healthy male volunteers after single oral administration of Sho-seiryu-to (extract) by introducing the inter-individual variations.
On the results, we simulate the plasma concentration in multiple oral administrations.
