Analysis of Regulatory Effects of Gorei-san on Circulatory, Metabolic and Diuretic Function. Especially in relation to a participation of endothelial ectivation and increase of urinary 6-keto-prostaglandin F1.ALPHA. level.
10.3937/kampomed.42.313
- VernacularTitle:五苓散の通陽化気・利水作用の解析 とくに血管内皮細胞賦活作用と尿中６ケトプロスタグランジンＦ１α排せつ量増加作用の関与について
- Author:
Masatake SEKI
;
Masashi FUJIOKA
;
Takashi HATANO
;
Hiroshi IKEDA
- Publication Type:Journal Article
- From:Kampo Medicine
1992;42(3):313-322
- CountryJapan
- Language:Japanese
-
Abstract:
The regulatory effects of Gorei-san (Wu-Ling-San) on circulatory, metabolic and diuretic function were investigated analyzing the perioperative transition of serum sodium levels, peripheral platelet counts and urinary 6-keto-prostaglandin F1α levels in fifty-eight female patients who underwent cholecystectomy because of cholelithiasis or gallbladder polyps.
The endothelial cells were considered to be activated by administration of Goreisan as shown by an increase of prostaglandin I2 production, resulting in circulatory and metabolic stimulation and partly promotion of diuretic function by a dilatation of the renal vessels. The urinary 6-keto-prostaglandin F1α, a metabolite of serum prostaglandin I2 and also excreted by the interstitial cells in the renal medulla or by the epithelial cells of the renal collecting tubules, was considered to regulate diuretic function through suppressing the antidiuretic hormone.
The phenomena mentioned above were not recognized when Sho-saiko-to (Xiao-Chai-Hu-Tang) was administered instead of Gorei-san.
