Alkaloid constitution in "Uzu" and "Shujibushi", as well as alkaloid contents in their decoction.
10.3937/kampomed.39.33
- VernacularTitle:修治附子および鳥頭含有アルカロイドの組成ならびにその煎液中への移行に関する研究
- Author:
Kohshiro CHIKAZAWA
;
Shigeo ARAKI
;
Taroh TAMADA
;
Kiyoo ITOH
;
Hiroshi ITOH
;
Motoo ARAI
- Publication Type:Journal Article
- From:Kampo Medicine
1988;39(1):33-40
- CountryJapan
- Language:Japanese
-
Abstract:
In order to reduce the side effects of aconitine alkaloids, various types of processed Aconitine Tuber have been developed. We have been using 2 types of processed materials: the “Shujibushi” and the “Uzu” for the treatment of rheumatoid arthritis.
Original forms of aconitines (aconitine, hypaconitine and mesaconitine) and total alkaloids of these processed materials were analyzed. Hypaconitine content was 4.9 times larger in the “Uzu” than in the “Shujibushi”. In contrast, the content of total alkaloids was significantly larger in the “Shujibushi” than in the “Uzu”. Accordingly, the amount of total alkaloids eluted to the decoction was 1.3-1.8 times larger in the “Shujibushi” than in the “Uzu”.
Our data indicate that 1) The effectiveness of the processed Aconiti Tuber may depend on the contents of the total alkaloids as well as the original forms of aconitines; 2) Elution rates of total alkaloids to the decoction vary among the types of herb complex resulting in the difference of their clinical effectiveness and reduction of side effects.
