Inhibitory effects on the generation of oxygen radical and the release of slow reacting substance of anaphylaxis(SRS-A).
10.3937/kampomed.38.25
- VernacularTitle:清肺湯に関する研究 活性酸素およびＳＲＳ‐Ａ遊離に対する抑制効果
- Author:
Kohji MIYAMOTO
;
Ataru KUROIWA
;
Hidechika OKADA
;
Tatsuo FURUKAWA
- Publication Type:Journal Article
- From:Kampo Medicine
1987;38(1):25-30
- CountryJapan
- Language:Japanese
-
Abstract:
Oral administration of Qing-Fei-Tang improved symptoms of a patient suffering from acute bronchitis with severe cough and sputum. Chemiluminescence (CL) of oxygen radical stimulated by opsonized zymosan in the peripheral blood of the patient was abnormally high before administration of Qing-Fei-Tang. The elevated CL was normalized after 5 week-administration of the drug. In vitro study, Qing-Fei-Tang suppressed in a dose dependent manner the CL of oxygen radical generation in normal human leukocytes stimulated by opsonized zymosan, and also inhibited a release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung tissues after antigen challenge. These results suggest the suppression by Qing-Fei-Tang of release of a chemical mediator, like SRS-leukotriene, may be involved in the improvement of symptoms of the acute bronchitis.
