The Effect of FR-167653 on Postoperative Intimal Hyperplasia of the Interposition Vein Graft in Rat.
10.4326/jjcvs.31.173
- VernacularTitle:ラットｉｎｔｅｒｐｏｓｉｔｉｏｎ ｖｅｉｎ ｇｒａｆｔにおけるＴＮＦ‐α産生阻害剤ＦＲ‐１６７６５３の術後内膜肥厚抑制効果について
- Author:
Mitsuhiro Yamamura
;
Takashi Miyamoto
;
Hideki Yao
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor-α (TNF-α);
FR-167653
- From:Japanese Journal of Cardiovascular Surgery
2002;31(3):173-176
- CountryJapan
- Language:Japanese
-
Abstract:
Recently we reported that tumor necrosis factor-α (TNF-α) mRNA expression and the development of postoperative intimal hyperplasia (IH) is different in rat epigastric vein interposition graft, compared to femoral artery re-anastomosis. We evaluated whether a TNF-α suppressive agent, FR-167653 (Fujisawa Pharm. Co., Ltd., Osaka) could suppress IH or not. Eleven Lewis male rats (480±8g) were studied. The epigastric vein graft was interposed into the common femoral artery. They were divided into two groups: group FR (n=5) with 2.0μg/g of FR-167653, and group C (n=6) with same dose of saline instead of FR-167653. The intimal areas of vein grafts were measured at 4 weeks postoperatively. The mean intimal area in group FR was significantly decreased, compared with group C (0.160±0.057mm2 vs. 0.434±0.045mm2, p<0.01). These results suggest that the TNF-α suppressive agent FR-167653 may suppress the postoperative intimal hyperplasia that occurs on the interposition vein graft in rats.
