Role of Neutrophils in Pulmonary Dysfunction during Cardiopulmonary Bypass.
10.4326/jjcvs.29.363
- VernacularTitle:体外循環中の肺機能障害に対する好中球の関与
- Author:
Hidenori Gohra
;
Tomoe Katoh
;
Toshiro Kobayashi
;
Masahiko Nishida
;
Ken Hirata
;
Akihito Mikamo
;
Haruhiko Okada
;
Kimikazu Hamano
;
Nobuya Zempo
;
Kensuke Esato
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
2000;29(6):363-367
- CountryJapan
- Language:Japanese
-
Abstract:
To test the hypothesis that neutrophils play a role in lung injury during cardiopulmonary bypass, granulocyte elastase and myeloperoxidase release from pulmonary circulation were measured, as well as the respiratory index, before and after cardiopulmonary bypass. The production of granulocyte elastase and myeloperoxidase in the pulmonary circulation, and the respiratory index also elevated significantly after cardiopulmonary bypass. Furthermore, the level of granulocyte elastase and myeloperoxidase released from pulmonary circulation correlated with the changes of the respiratory index and preoperative pulmonary artery pressure. These data indicate that neutrophils play a major role in pulmonary dysfunction occurring after cardiopulmonary bypass, which is accentuated in patients with pulmonary hypertension.
