Ulcerative Colitis and Immunoglobulin G4.
- Author:
Go KUWATA
1
;
Terumi KAMISAWA
;
Koichi KOIZUMI
;
Taku TABATA
;
Seiichi HARA
;
Sawako KURUMA
;
Takashi FUJIWARA
;
Kazuro CHIBA
;
Hideto EGASHIRA
;
Junko FUJIWARA
;
Takeo ARAKAWA
;
Kumiko MOMMA
;
Shinichiro HORIGUCHI
Author Information
1. Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. kamisawa@cick.jp
- Publication Type:Original Article
- Keywords:
Colitis, ulcerative;
Immunoglobulin G;
Autoimmune pancreatitis
- MeSH:
Adult;
Aged;
Colitis, Ulcerative/*blood/complications;
Colon/*chemistry;
Female;
Humans;
Immunoglobulin G/*analysis;
Intestinal Mucosa/*chemistry;
Male;
Middle Aged;
Pancreatitis/*blood/complications;
Retrospective Studies
- From:Gut and Liver
2014;8(1):29-34
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4. METHODS: Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients. RESULTS: UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05). CONCLUSIONS: UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
