Clinical Features, Image Findings, and Prognosis of Inflammatory Pseudotumor of the Liver: A Multicenter Experience of 45 Cases.
- Author:
Jun Young PARK
1
;
Moon Seok CHOI
;
Young Suk LIM
;
Jang Won PARK
;
Seung Up KIM
;
Yang Won MIN
;
Geum Youn GWAK
;
Yong Han PAIK
;
Joon Hyoek LEE
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Byung Chul YOO
Author Information
1. Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. drmschoi@gmail.com
- Publication Type:Original Article ; Multicenter Study
- Keywords:
Inflammatory pseudotumor;
Liver
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Contrast Media/diagnostic use;
Female;
Granuloma, Plasma Cell/*diagnosis/therapy;
Humans;
Liver Diseases/*diagnosis/therapy;
Magnetic Resonance Imaging/methods;
Male;
Middle Aged;
Prognosis;
Tomography, X-Ray Computed/methods
- From:Gut and Liver
2014;8(1):58-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. METHODS: Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. RESULTS: They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). CONCLUSIONS: CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.
