Synthesis of bicuculin by direct condensation method meconin with isoquinolinium iodid salt
- Author:
Nguyen Dinh Luyen
- Publication Type:Journal Article
- Keywords:
Direct condensation method meconin
- MeSH:
Pharmaceutical Preparations;
Chromatography
- From:Pharmaceutical Journal
2005;353(9):12-15
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Using direct condensation method meconin with isoquinolinium isodid salt, the authors had synthesized of bicuculin by a new method. With this method, an important intermediacy - erythro cordrastin isomer - was created with the greater rate in comparison with threo isomer. Two isomers were separated easily due to silicagel chromatography. The erythro isomer was demethylated by BBr3 reagent. Methylenation of tetrahydroxy compound provided bicuculline racemic. Separate the contrasts of bicucullin racemic by acid D (+) could help to obtain (+) bicucullin with high optical purify which were reached standards for next biological tests
