Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma.
- Author:
Gu Hyum KANG
1
;
Byung Seok LEE
;
Eaum Seok LEE
;
Seok Hyun KIM
;
Heon Young LEE
;
Dae Young KANG
Author Information
1. Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. gie001@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
p53;
mTOR;
c-Met;
Receptor, IGF type 1;
Carcinoma, hepatocellular
- MeSH:
Adult;
Aged;
Carcinoma, Hepatocellular/*metabolism/surgery;
Disease-Free Survival;
Female;
HSP70 Heat-Shock Proteins/metabolism;
Humans;
Liver Neoplasms/*metabolism/surgery;
Male;
Middle Aged;
Prognosis;
Proto-Oncogene Proteins c-met/metabolism;
Receptor, IGF Type 1/metabolism;
Retrospective Studies;
Risk Factors;
TOR Serine-Threonine Kinases/metabolism;
Treatment Outcome;
Tumor Markers, Biological/*metabolism;
Tumor Suppressor Protein p53/metabolism
- From:Gut and Liver
2014;8(1):79-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We analyzed the immunohistochemical expression of p53, mammalian target of rapamycin (mTOR), c-Met, and insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) with the clinicopathologic features of 83 HCCs. RESULTS: p53 expression was higher in the male patients with undifferentiated histological tumor grades, cirrhosis, and portal vein invasion. High 48 c-Met expression correlated with cirrhosis, and high mTOR expression correlated with the tumor grade and cirrhosis. High IGF-1R expression correlated with the tumor grade and cirrhosis. A multivariate analysis identified a significant relationship between the high expression of p53, tumor grade, and portal vein invasion. In addition, a high expression of mTOR was related to tumor grade and cirrhosis, and a high expression of HSP70 was related to portal vein invasion in a multivariate analysis. The Kaplan-Meier survival curve for patients with high versus low Edmondson grades and p53 expression was statistically significant. CONCLUSIONS: p53, mTOR, and IGF-1R expression correlated with the Edmondson tumor grade in a univariate analysis, while p53 and mTOR correlated with the Edmondson tumor grade in a multivariate analysis. In addition, the tumor grade was found to predict survival. p53 was primarily related to the clinicopathologic features compared to other markers, and it is a poor prognostic factor of survival.
