Differential Expression of E-Cadherin, beta-Catenin, and S100A4 in Intestinal Type and Nonintestinal Type Ampulla of Vater Cancers.
- Author:
Rohyun SUNG
1
;
Li KANG
;
Joung Ho HAN
;
Jae Woon CHOI
;
Sang Hwa LEE
;
Tae Hoon LEE
;
Sang Heum PARK
;
Hong Ja KIM
;
Eaum Seok LEE
;
Young Suk KIM
;
Young Woo CHOI
;
Seon Mee PARK
Author Information
1. Department of Pathology, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea.
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Ampullary adenocarcinoma;
Intestinal type;
Pancreatobiliary type;
Epithelial-mesenchymal transition
- MeSH:
Aged;
Aged, 80 and over;
Ampulla of Vater/*metabolism;
Cadherins/metabolism;
Common Bile Duct Neoplasms/classification/*metabolism;
Disease-Free Survival;
Female;
Humans;
Male;
Middle Aged;
Prognosis;
Retrospective Studies;
S100 Proteins/metabolism;
Tumor Markers, Biological/*metabolism;
beta Catenin/metabolism
- From:Gut and Liver
2014;8(1):94-101
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Epithelial-mesenchymal transition (EMT)-related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs). We evaluated the expression of E-cadherin, beta-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival. METHODS: A clinicopathological review of 105 patients with AVCs and immunohistochemical staining for E-cadherin, beta-catenin, and S100A4 were performed. The association between clinicopathological parameters, histological type, and expression of EMT proteins and their effects on survival were analyzed. RESULTS: Sixty-five intestinal type, 35 pancreatobiliary type, and five other types of AVCs were identified. The severity of EMT changes differed between the AVC types; membranous loss of E-cadherin and beta-catenin was observed in nonintestinal type tumors, whereas aberrant nonmembranous beta-catenin expression was observed in intestinal type tumors. EMT-related changes were more pronounced in the invasive tumor margin than in the tumor center, and these EMT-related changes were related to tumor aggressiveness. Among the clinicopathological parameters, a desmoplastic reaction was related to overall survival, and the reaction was more severe in nonintestinal type than in intestinal type AVCs. CONCLUSIONS: Dysregulation of E-cadherin, beta-cadherin, and S100A4 expression may play a role in the carcinogenesis and tumor progression of AVCs.
