Is a Preoperative Assessment of the Early Recurrence of Pancreatic Cancer Possible after Complete Surgical Resection?.
- Author:
Marco LA TORRE
1
;
Giuseppe NIGRI
;
Annalisa LO CONTE
;
Federica MAZZUCA
;
Simone Maria TIERNO
;
Adelona SALAJ
;
Paolo MARCHETTI
;
Vincenzo ZIPARO
;
Giovanni RAMACCIATO
Author Information
1. Department of General Surgery, Biomedical Technologies and Translational Medicine, St. Andrea Hospital, University of Rome La Sapienza Faculty of Medicine and Psychology, Rome, Italy. marco.latorre@uniroma1.it
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pancreatic neoplasms;
Early recurrence;
Preoperative CA 19-9;
Prognosis;
Pancreatic adenocarcinoma
- MeSH:
Adenocarcinoma/*diagnosis/surgery;
Aged;
CA-19-9 Antigen/blood;
Feasibility Studies;
Female;
Humans;
Male;
*Models, Biological;
Neoplasm Recurrence, Local/*diagnosis;
Pancreatic Neoplasms/*diagnosis/surgery;
Prognosis;
Retrospective Studies;
Tumor Markers, Biological/*blood
- From:Gut and Liver
2014;8(1):102-108
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival. The aim of this study was to identify preoperative prognostic factors and to create a prognostic model able to assess the early recurrence risk for patients with resectable PAC. METHODS: A series of 177 patients with PAC treated surgically at the St. Andrea Hospital of Rome between January 2003 and December 2011 were reviewed retrospectively. Univariate and multivariate analyses were utilized to identify preoperative prognostic indicators. RESULTS: A preoperative CA 19-9 level >228 U/mL, tumor size >3.1 cm, and the presence of pathological preoperative lymph nodes statistically correlated with early recurrence. Together, these three factors predicted the possibility of an early recurrence with 90.4% accuracy. The combination of these three preoperative conditions was identified as an independent parameter for early recurrence based on multivariate analysis (p=0.0314; hazard ratio, 3.9811; 95% confidence interval, 1.1745 to 15.3245). CONCLUSIONS: PAC patient candidates for surgical resection should undergo an assessment of early recurrence risk to avoid unnecessary and ineffective resection and to identify patients for whom palliative or alternative treatment may be the treatment of choice.
