Effects of Single Administration of Milrinone during Cardiopulmonary Bypass.
10.4326/jjcvs.27.288
- VernacularTitle:人工心肺中ミルリノン単回静注の有用性に関する臨床的研究
- Author:
Yoshihiro Hamada
;
Kanji Kawachi
;
Tetsuya Yamamoto
;
Tatsuhiro Nakata
;
Yasuaki Kashu
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1998;27(5):288-292
- CountryJapan
- Language:Japanese
-
Abstract:
We investigated the effects of milrinone administered during cardiopulmonary bypass (CPB) for open heart surgery. Ten patients (group M) received milrinone after aortic declamping during CPB. Ten other patients served as controls with no administration (group C). Soon after the bolus infusion of milrinone, the perfusion pressure dropped significantly in the M group, however, after CPB and at the end of operation, aortic pressure showed no difference between the two groups. There were no differences in heart rate, pulmonary artery pressure and pulmonary capillary wedge pressure. After CPB, cardiac index was high and systemic vascular resistance index was low in the M group. The need for cathecholamine and time for rewarming showed also no significant differences. No adverse reaction was recognized. During CPB, a single administration of milrinone was useful for peri- and post-operative management of patients undergoing open heart surgery.
