The Role of Cytokines (IL-8 and IL-10) in Reperfusion Injury Following Acute Arterial Occlusion of the Extremities.
10.4326/jjcvs.27.282
- VernacularTitle:急性動脈閉塞症の再潅流障害におけるサイトカインの実験的検討 ＩＬ‐８，ＩＬ‐１０について
- Author:
Shinsuke Choh
- Publication Type:Journal Article
- Keywords:
IL-8;
IL-10
- From:Japanese Journal of Cardiovascular Surgery
1998;27(5):282-287
- CountryJapan
- Language:Japanese
-
Abstract:
To evaluate the role of interleukin-8 (IL-8) and interleukin-10 (IL-10) in reperfusion injury following acute arterial occlusion, an experimental study was carried out using Wistar strain rats. The reperfusion injury model was conducted in 4 rats, in which the infra-renal aorta and the bilateral common femoral artery were ligated for 6 hours and then released (Group I). In controls, only preparation of these arteries without clamping were performed in 4 rats (Group II). In both groups, creatine phosphokinase (CPK), IL-8 and IL-10 were measured and compared. In group I, CPK was significantly higher than in Group II after the ligation and the reperfusion. After the reperfusion, IL-8 increased significantly, remaining at a high value in group I. The IL-10 of Group I also increased significantly and indicated high 6 hours after the reperfusion, however, it significantly decreased 12 hours after the reperfusion. These results suggests that the high value of IL-8, which is inflammation-linked cytokine, and the low level of IL-10, an anti-inflammatory cytokine, may prolong the systemic inflammatory response. The imbalance of these two kinds of cytokines may play an important role in the incidence of reperfusion injury and myonephropathic metabolic syndrome, which is a fatal complication after acute arterial occlusion disease.
