A Multicenter Trial of Anticoagulant Therapy after Cardiac Valve Replacement.
10.4326/jjcvs.26.169
- VernacularTitle:人工弁置換術後の抗凝血薬療法に関する多施設間レトロスペクティブ調査について（ＴＡＳ‐Ｔｒｉａｌ）
- Author:
Tatsuhiko Kudo
;
Mitsuhiko Kawase
;
Shiaki Kawada
;
Hiromi Kurosawa
;
Hitoshi Koyanagi
;
Yasuo Takeuchi
;
Yasuyuki Hosoda
;
Yasuhiko Wanibuchi
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1997;26(3):169-174
- CountryJapan
- Language:Japanese
-
Abstract:
The authors examined the frequency of thromboembolism and bleeding complications in cases of mechanical valve replacement during the past 5 years in the Tokyo area. There were 21 cases of thromboembolism and 15 cases of bleeding complications. Analyzing these cases with regard to anticoagulant therapy, 71% of the thromboembolism cases and 47% of the bleeding complication cases had 10∼25% result on the thrombotest at the time of the event. Consequently, in cases of mechanical valve replacement it is necessary to reevaluate the therapeutic range of the thrombotest results. This was a retrospective study of a TAS (The Tokyo area anticoagulation study for cardiac valve replacement by using PT-INR) trial and we intend to carry out a prospective study on the therapeutic range of the thrombotest and PT-INR.
