Thrombomodulin Concentration in Patient Undergoing Surgery for Abdominal Aortic Aneurysm.

VernacularTitle:血中トロンボモジュリン値からみた腹部大動脈りゅう手術時の血管内皮障害の判定
Author: Takaaki Sugita ; Shoji Watarida ; Kazuhiko Katsuyama ; Yasuhiko Nakajima ; Rie Yamamoto ; Atsumi Mori
Publication Type:Journal Article
From:Japanese Journal of Cardiovascular Surgery 1997;26(2):87-89
CountryJapan
Language:Japanese
Abstract: Thrombomodulin is an endothelial cell membrane protein that is released into the blood in soluble forms in response to endothelial damage. We evaluated thrombomodulin in blood samples taken from the femoral vein before, during and after elective surgery for abdominal aortic aneurysm in 9 patients. Thrombomodulin was measured using an ETA assay. Thrombomodulin decreased significantly just before aortic declamp from before surgery (p<0.001), and remained unchanged just after and 1 hour after aortic declamp. Three hours after aortic declamp, thrombomodulin increased significantly from 1 hour after aortic declamp (p<0.01), peaked at 6 hours after aortic declamp and then decreased. These data suggest that thrombomodulin did not increase significantly during surgery for abdominal aortic aneurysm.