Effects of Granulocytic Elastase and Fibronectin on the Coagulation and Fibrinolytic System when using Cardiopulmonary Bypass.
10.4326/jjcvs.25.26
- VernacularTitle:人工心肺下開心術におけるか粒球エラスターゼ，フィブロネクチンが凝固線溶系に与える影響
- Author:
Tadashi Ozaki
;
Jiro Kondo
;
Hideshi Kurata
;
Kiyotaka Imoto
;
Michio Tobe
;
Akira Sakamoto
;
Akihiko Matsumoto
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1996;25(1):26-30
- CountryJapan
- Language:Japanese
-
Abstract:
We studied the effects of granulocytic elastase (GEL) and fibronectin (FN) on the coagulation and fibrinolytic system when using cardiopulmonary bypass (CPB). Blood sampling was performed before CPB (Pre), just after CPB (Post) the 1st postoperative day (PD1) and the second postoperative day (PD2). Laboratory parameters were GEL, FN, fibrinogen (Fib), prothrombin time (PT), fibrin degradation products (FDP), D dimer (D-D), α2 plasmin inhibitor plasmin complex (PIC) and antithrombin III (AT III). The level of GEL was highest and that of FN was lowest at Post. The levels of Fib, PT and AT III were lowest and that of PIC was highest just after CPB. The levels of FDP and D-D were highest on PD1. The levels of GEL and D-D correlated just after CPB and on PD1 and PD2. The level of GEL correlated with that of PIC on PD1. These results demonstrated that the level of FN decreased with CPB. And it was expected that CPB time affected the level of GEL. The levels of GEL affects D-D and PIC which are fibrinolysic factors particularly related to secondary fibrinolysis.
