Excellent Hemostatic Effects of Aprotinin in Coronary Artery Bypass Surgery and Some Problems.
10.4326/jjcvs.23.404
- VernacularTitle:アプロチニン使用による冠状動脈デバイス術時の止血効果とその問題点
- Author:
Tatsuo Kaneko
;
Toshio Konishi
;
Tamiyuki Obayashi
;
Toshihide Ohki
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1994;23(6):404-408
- CountryJapan
- Language:Japanese
-
Abstract:
To determine the hemostatic effets of aprotinin in coronary artery bypass surgery, a prospective study was performed. Thirty four patients (group A) who received aprotinin (2×106 unit) in the cardiopulmonary circuit were compared with 31 control patients (group C) who did not. Activated clotting time was measured in group A for 60 minutes during cardiopulmonary bypass, but no significant difference was observed in the platelet counts of the two groups. Intraoperative blood loss was 366ml in group A compared with 514ml in group C, and postoperative blood loss was 354ml versus 570ml, respectively (p<0.05). Total blood loss was significantly reduced in group A by 34% compared with group C (720ml versus 1, 084ml, p<0.05). There was no difference in incidence of perioperative myocardial damage. It seems necessary to investigate the complications of the hemostatic effects of aprotinin and it effects on graft patency.
