Comparison of 4 L of PEG Versus Combination of 2 L of PEG and 45 mL of Sodium Phosphate for Colonoscopy Colon Cleansing: A Prospective Randomized Trial.
- Author:
Jong Jin HYUN
1
;
Yoon Tae JEEN
;
Sang Hoon PARK
;
Beom Jae LEE
;
Jong Hwan CHOI
;
Hwang Rae CHUN
;
Rok Son CHOUNG
;
Yong Sik KIM
;
Hoon Jai CHUN
;
Hong Sik LEE
;
Soon Ho UM
;
Sang Woo LEE
;
Jai Hyun CHOI
;
Chang Duck KIM
;
Ho Sang RYU
;
Jin Hai HYUN
Author Information
1. Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea. ytjeen@korea.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Colonoscopy;
Colon cleansing;
Polyethyleneglycol;
Sodium phosphate
- MeSH:
Colon*;
Colonoscopy*;
Compliance;
Detergents;
Humans;
Korea;
Nausea;
Phosphorus;
Prospective Studies*;
Sodium*
- From:Korean Journal of Gastrointestinal Endoscopy
2005;31(6):368-373
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Polyethyleneglycol (PEG) is safe but its large volume and bad taste reduces patients' compliance. Sodium phosphate (NaP) is a hyperosmotic agent and its small volume can increase patients' compliance but electrolyte imbalance is a problem. Therefore, we conducted a study to determine whether patients' compliance can be enhanced and electrolyte imbalance reduced by combining these two agents. METHODS: Forty-one admitted patients receiving colonoscopy at Korea University Hospital from June 28, 2004 to August 14, 2004 were randomly divided into two groups for colon cleansing with either PEG 4 L (n=21) or PEG 2 L plus NaP 45 mL (n=20). Patients were assessed for patient tolerance, quality of preparation, and changes of biochemical parameters. RESULTS: Overall discomfort was statistically lower in the combination group, PEG 2 L plus NaP 45 mL (p=0.035). Although patients in the combination group reported less fullness (p=0.076) and nausea (p=0.087), the findings were not statistically significant. The quality of the preparation was comparable between the two groups (p=0.872). The phosphorus level in the combination group showed a statistically significant increase (0.58+/-0.46) after colon cleansing (p=0.020) but was not clinically significant. CONCLUSIONS: The combination of NaP 45 mL and PEG 2 L showed less overall discomfort with comparable quality of preparation and without serious electrolyte abnormality compared to 4 L of PEG. Therefore, the combination of NaP 45 mL and PEG 2 L could be used as an alternative colonoscopic colon cleansing agent when patients have trouble taking 4 L of PEG alone.
