Two Cases of Granulocytosis Treated Successfully with Recombinant Granulocyte Colony Stimulating Factor(G-CSF) after Cardiac Surgery.
10.4326/jjcvs.22.414
- VernacularTitle:開心術後のか粒球減少症に対し遺伝子組替えか粒球コロニー刺激因子（ｒｈＧ‐ＣＳＦ）が奏効した２症例
- Author:
Akihiko USUI
;
Mitsuo KAWAMURA
;
Michiaki HIBI
;
Kousei SATOU
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1993;22(5):414-416
- CountryJapan
- Language:Japanese
-
Abstract:
Two cases of granulocytosis after cardiac surgery were treated successfully with a recombinant granulocyte colony stimulating factor (rhG-CSF). Case 1 was a 65-year old man who underwent a double valve replacement due to infective endocarditis. As his white blood cell counts decreased to 1, 000/mm3 on the 24th postoperative day due to long-term antibiotic therapy, 125μg of rhG-CSF was given intracutaneously for 7 days. White blood cell counts increased after the 27th postoperative day and reached 15, 500/mm3 on the 30th postoperative day. The patient became afebrile immediately after administration of rhG-CSF. Case 2 was a 70-year-old man who suffered pneumonia after aortocoronary bypass surgery. As his white blood ceell counts decreased to 2, 300/mm3 on the 21st postoperative day, 80μg of rhG-CSF was given intracutaneously for 7 days. He became afebrile after the 22nd postoperative day and his white blood cell counts increased 18, 200/mm3 on the 28th postoperative day. rhG-CSF not only increases white blood cell counts but also reduces infectious symptoms and therefore is effective in managing granulocytosis after cardiac surgery.
