Impact of age on the false negative rate of human papillomavirus DNA test in patients with atypical squamous cells of undetermined significance.
10.5468/ogs.2015.58.2.117
- Author:
Kyu Hee WON
1
;
Jae Yeon LEE
;
Hye Yon CHO
;
Dong Hoon SUH
;
Jae Hong NO
;
Yong Beom KIM
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Age;
Atypical squamous cells of the cervix;
Human papillomavirus DNA tests;
Uterine cervical dysplasia
- MeSH:
Cervical Intraepithelial Neoplasia;
DNA*;
Human Papillomavirus DNA Tests;
Humans;
Prevalence;
Triage;
Uterine Cervical Dysplasia
- From:Obstetrics & Gynecology Science
2015;58(2):117-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Human papillomavirus (HPV) test was incorporated into the triage of lesser abnormal cervical cytologies: atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL). This study aimed to evaluate the impact of age on the efficacy of HPV testing in patients with lesser abnormal cervical cytologies. METHODS: A total of 439 patients with ASCUS or LSIL were included. The association between age groups and the diagnostic performances of HPV test for high-grade cervical intraepithelial neoplasia (CIN2+) was evaluated. RESULTS: Median age was 44 years (range, 17 to 75 years). ASCUS was more frequently observed in older patients while LSIL was more common in younger patients (P=0.002). CIN2+ was found in 11.3% (32/284) of the ASCUS patients and 12.9% (20/155) of patients with LSIL. Older patients with ASCUS showed lower HPV infection rates (P=0.025), but not LSIL (P=0.114). However, the prevalence of CIN2+ was similar between the age groups with ASCUS or LSIL. In patients with ASCUS, the false negative rate of HPV test for CIN2+ was 6.2%. The false negative rate of the HPV test became higher with increasing of the age after the age of 50 (P=0.034). CONCLUSION: Our findings suggest that false negative rate of the HPV test for CIN2+ in ASCUS patients older than 50 years might become higher with increasing of the age. Negative HPV results in patients of the age >50 years with ASCUS should be carefully interpreted.
