Biochemical Changes of Venous Blood in Abdominal Aortic Surgery: Malondialdehyde Changes in Venous Blood.
10.4326/jjcvs.20.1483
- VernacularTitle:腎動脈下腹部大動脈りゅう手術に伴う血液生化学的変化 血中過酸化脂質の変動について
- Author:
Nobuo HATORI
;
Eriya OKUDA
;
Yozo URIUDA
;
Masafumi SHIMIZU
;
Yoshiyuki HAGA
;
Hiroshi YOSHIZU
;
Susumu TANAKA
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1991;20(9):1483-1488
- CountryJapan
- Language:Japanese
-
Abstract:
The procedure of cross clamping and declamping of the infra-renal abdominal aorta is common in the reconstructive abdominal aortic surgery. However, little is known to the oxygen free radical formations during the surgery. To evaluate the oxygen radical production, the malondialdehyde (MDA) levels in venous blood were measured prior to, during and after the operation with other metabolites such as C3, C3a, granulocytes, CPK, amylase, BUN, creatinine, beta-2-microglobulin, total protein (TP), hematocrit (Ht), GOT, GPT, LDH, lactate, potassium, and myoglobulin in ten patients of the infra-renal aortic aneurysm. The average of the aortic occlusion time was 63±18min in the patients. The levels of MDA (from 3.2±0.7nmol/ml to 2.3±0.5nmol/ml), C3, TP and Ht were decreased during the operation and there were significant correlations between the levels of MDA (r=0.486, p<0.01), C3 (r=0.59, p<0.01) and TP. It is, therefore, likely that the reduction of MDA and C3 levels is due to the blood dilution by the bleeding, fluid infusion and blood transfusion during the operation. The levels of C3a did not increase during and after the operation. The levels of CPK (from 73±40U/l to 920±705U/l) and amylase (from 183±87U/l to 444±420U/l) were temporary increased on the first day after the operation. The level of lactate was increased during the occlusion of the aorta (from 9.0±3.0mg/dl to 20.2±5.8mg/dl) and until the just after the operation (23.2±18.6mg/dl). The other metabolites such as GOT, GPT, BUN, creatinine and beta-2 microglobulin did not change throughout the investigation period. There was a substantial ischemia of lower extremities during the aortic occlusion resulted in significant increase of lactate level. These results suggest that the temporary occlusion of the infra-renal aorta during the common reconstructive abdominal aortic surgry does not produce the oxygen free radical formation which increases the lipidperoxidation level in the systemic circulation.
