Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women.
10.5468/ogs.2015.58.2.144
- Author:
Seok Kyo SEO
1
;
Bo Hyon YUN
;
Eun Bee NOE
;
Jong Wook SUH
;
Young Sik CHOI
;
Byung Seok LEE
Author Information
1. Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. dr222@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone density;
Coronary artery disease;
Menopause
- MeSH:
Absorptiometry, Photon;
Bone Density*;
Coronary Artery Disease*;
Female;
Femur Neck;
Health Promotion;
Humans;
Menopause;
Multidetector Computed Tomography;
Retrospective Studies;
Risk Factors;
Spine
- From:Obstetrics & Gynecology Science
2015;58(2):144-149
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study aimed to assess the association between bone mineral density (BMD) and coronary atherosclerosis in healthy postmenopausal women. METHODS: We performed a retrospective review of 252 postmenopausal women who had visited a health promotion center for a routine checkup. BMD of the lumbar spine (L1-L4) and femoral neck was evaluated using dual-energy X-ray absorptiometry, and coronary atherosclerosis was assessed using 64-row multidetector computed tomography. Participants were divided into normal BMD and osteopenia-osteoporosis groups, according to the T-scores of their lumbar spine or femoral neck. RESULTS: Participants with osteopenia-osteoporosis had a significantly higher proportion of coronary atherosclerosis than did those with normal BMD at the lumbar spine (P=0.003) and femoral neck (P=0.004). Osteopenia-osteoporosis at the lumbar spine (odds ratio [OR], 2.86; 95% confidence interval [CI], 1.12 to 7.27) or femoral neck (OR, 3.35; 95% CI, 1.07 to 10.57) was associated with coronary atherosclerosis, after controlling for age and cardiovascular risk factors. CONCLUSION: Decreased BMD is associated with coronary atherosclerosis in healthy postmenopausal women, independent of age and cardiovascular risk factors. Postmenopausal women with decreased BMD may have a higher risk of developing coronary atherosclerosis.
