Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia.
10.5468/ogs.2015.58.2.157
- Author:
Bulent CAKMAK
1
;
Selim GULUCU
;
Nurlan ALIYEV
;
Zeki OZSOY
;
Mehmet NACAR
;
Dogan KOSEOGLU
Author Information
1. Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey. drbulentcakmak@hotmail.com
- Publication Type:Original Article
- Keywords:
Atypia;
Blood cells;
Endometrial hyperplasia;
Inflammatory;
Markers
- MeSH:
Blood Cell Count;
Blood Cells;
Curettage;
Endometrial Hyperplasia*;
Female;
Humans;
Hyperplasia;
Leukocytes;
Neutrophils;
Platelet Count;
Uterine Hemorrhage
- From:Obstetrics & Gynecology Science
2015;58(2):157-161
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of present study was to evaluate association between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and endometrial hyperplasia (EH). METHODS: One hundred and ten women with abnormal uterine bleeding were included into the study. Blood samples were drawn from all patients to obtain complete blood cell counts, neutrophil-leukocyte ratio and platelet-leukocyte ratio before endometrial curettage procedure initiated. The patients were divided into three groups due to their pathological results: group 1, patients with EH without atypia (n=40); group 2, patients with EH with atypia (n=15); and group 3, patients with neither hyperplasia nor cancer as control group (n=55). Blood cell counts, NLRs and PLRs were compared among these groups. RESULTS: Based on hemoglobin and platelet counts, there was no significant difference among these groups (P>0.05). Leukocyte and neutrophil counts were higher in group 2 (EH with atypia) than group 1 and group 3 (P<0.01). NLR of group 2 was significantly elevated when compared to group 1 and group 3 (P=0.004). PLR was higher in group 1 and group 2 than control group (P=0.024). CONCLUSION: Non-specific inflammatory markers such as NLR and PLR were elevated in women with atypical EH. These markers may be used as a predictor of atypical EH in patients with abnormal uterine bleeding.
