Renal Function after Cardiopulmonary Bypass and Effect of Urinastatin on Renal Function.
10.4326/jjcvs.20.1284
- VernacularTitle:体外循環後の腎機能およびウリナスタチンの腎保護作用
- Author:
Hidenori GOHRA
;
Shoichi FURUKAWA
;
Tatsuro ODA
;
Kensuke ESATO
- Publication Type:Journal Article
- From:Japanese Journal of Cardiovascular Surgery
1991;20(7):1284-1288
- CountryJapan
- Language:Japanese
-
Abstract:
To evaluate the renal function after cardiopulmonary bypass (CPB) and the effect of Urinastatin on renal function, the tubular and glomerular damage were studied in patients underwent cardiac operations, dividing following two groups; Group U with Urinastain and Group C without Urinastatin. Of indexes of glomerular function, changes in serum creatinine and urine nitrogen, and creatinine clearance did not show remarkably after CPB. Serum β2-microglobulin indicating glomerular function after CPB demonstrated significantly higher levels than that before operation in Group C, but did not in Group U. N-acetyl-β3-D-glucosaminidase and γ-glutamyl-transpeptidase in urine as markers of tubular function rose significantly after CPB in both groups, but they showed significantly lower level in Group U than in Group C. After CPB, even in patients without clinical renal failure, glomerular and tubular dysfunction were placed. Urinastatin was considered to be effective in protection of glomerular and tubular function.
