Surgical Experiences of Neuroendocrine Neoplasms of the Pancreas : Comparative Study of Functioning vs. Non-functioning Neoplasms.
- Author:
Byeong Kyu KIM
1
;
Chang Moo KANG
;
Jun Young KIM
;
Kyung Sik KIM
;
Jin Sub CHOI
;
Woo Jung LEE
;
Byong Ro KIM
Author Information
1. Department of Surgery Yonsei University College of Medicine, Korea. wjlee@yumc.younsei.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Neuroendocrine neoplasm;
Functioning;
Non-functioning;
Pancreas
- MeSH:
Disease-Free Survival;
Humans;
Medical Records;
Neoplasm Metastasis;
Pancreas*;
Prognosis;
Retrospective Studies
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2007;11(2):31-36
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Aims A neuroendocrine neoplasm (NEN) of the pancreas is rare, and can be divided into functioning and nonfunctioning NEN. This study was carried out to determine the characteristics and surgical outcomes of NEN of the pancreas experienced in a single institution. METHODS: The medical records of patients diagnosed with NEN of the pancreas (pancreatic islet-cell neoplasm) between June 1900 and June 2005 were retrospectively reviewed. RESULTS: A total of 33 patients with NEN of the pancreas were examined. Nineteen patients (57.6%) had a nonfunctioning NEN and 14 (42.4%) had a functioning NEN. By comparison, the tumor size (p=0.001), distant metastasis (p=0.042), malignant characteristics (p=0.010) and survival (p=0.002), were significantly different. Surgical resections were almost always possible in the cases of functioning NEN. Patients with functioning NENs of the pancreas had a significantly higher survival than those patients with nonfunctioning NENs (p=0.002). A curative resection provided a better survival outcome in patients with nonfunctioning NENs (p=0.005) and offered a more than 80% disease-free survival in those with functioning NENs of the pancreas. CONCLUSION: Nonfunctioning NENs of the pancreas appeared to be more aggressive than functioning NENs. A complete resection of the NENs of the pancreas can provide a good prognosis.
