Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study.
10.3803/EnM.2015.30.4.522
- Author:
Min Kyung LEE
1
;
Eun Jung RHEE
;
Min Chul KIM
;
Byung Sub MOON
;
Jeong In LEE
;
Young Seok SONG
;
Eun Na HAN
;
Hyo Sun LEE
;
Yoonjeong SON
;
Se Eun PARK
;
Cheol Young PARK
;
Ki Won OH
;
Sung Woo PARK
;
Won Young LEE
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. drlwy@hanmail.net
- Publication Type:Original Article
- Keywords:
Metabolic health;
Non-alcoholic fatty liver disease;
Obesity
- MeSH:
Blood Glucose;
Body Mass Index;
Cholesterol, HDL;
Fasting;
Fatty Liver*;
Follow-Up Studies;
Homeostasis;
Hypertension;
Obesity*;
Odds Ratio;
Retrospective Studies*;
Triglycerides;
Ultrasonography
- From:Endocrinology and Metabolism
2015;30(4):522-530
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study is to compare the risk for future development of nonalcoholic fatty liver disease (NAFLD) according to different status of metabolic health and obesity. METHODS: A total of 3,045 subjects without NAFLD and diabetes at baseline were followed for 4 years. Subjects were categorized into four groups according to the following baseline metabolic health and obesity statuses: metabolically healthy, non-obese (MHNO); metabolically healthy, obese (MHO); metabolically unhealthy, non-obese (MUHNO); and metabolically unhealthy, obese (MUHO). Being metabolically healthy was defined as having fewer than two of the following five components: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostasis model assessment-insulin resistance index. Obesity was defined as a body mass index >25 kg/m2. The presence of NAFLD was assessed by ultrasonography. RESULTS: The proportions of subjects included in the MHNO, MHO, MUHNO, and MUHO groups were 71.4%, 9.8%, 13.0%, and 5.8%, respectively. The proportions of subjects who developed NAFLD were 10.5%, 31.4%, 23.2%, and 42% in the MHNO, MHO, MUHNO, and MUHO groups, respectively. The risk for developing NAFLD was highest in subjects who were metabolically unhealthy both at baseline and after 4 years compared with subjects who were consistently metabolically healthy during the follow-up period (odds ratio, 2.862). Using the MHNO group as reference, the odds ratios for the MHO, MUHNO, and MUHO groups were 1.731, 1.877, and 2.501, respectively. CONCLUSION: The risk for NAFLD was lower in MHO subjects than in MUNO subjects.
