The effects of fracture fixation on joint contracture and disuse atrophy in immobilized rat soleus muscle
- VernacularTitle:骨折を伴う外固定が関節拘縮と廃用性筋萎縮に及ぼす影響
- Author:
Akira Nishikawa
;
Shunsuke Nishio
;
Akiko Nishikawa
;
Hidetaka Imagita
- Publication Type:Journal Article
- Keywords:
soleus muscle;
fracture fixation;
disuse atrophy;
range of motion
- From:Japanese Journal of Physical Fitness and Sports Medicine
2012;61(1):95-101
- CountryJapan
- Language:Japanese
-
Abstract:
In the present study, we investigated the effects of fracture fixation on joint contracture and disuse muscle atrophy. We surgically fractured the right hind limbs of male Wistar rats, and then fixed the right ankle joints at maximal plantar flexion for two weeks using dorsal splints. Compared with immobilized healthy and sham operated joints, the fractured joints concomitantly showed highly restricted range of motion and significantly higher degrees of disuse atrophy in soleus muscle; decrease of muscle fiber cross sectional area, development of central core lesion and a change in myosin heavy chain isoforms from slow type myosin to fast type myosin. Therefore, it is suggested that orthopedic fracture fixation induces intense disuse muscle atrophy to aggravate joint contracture.
