MicroRNAs in skeletal muscle
- VernacularTitle:骨格筋とマイクロRNA
- Author:
Takayuki Akimoto
;
Shuji Sawada
- Publication Type:Journal Article
- Keywords:
exercise;
training;
translation;
transcription
- From:Japanese Journal of Physical Fitness and Sports Medicine
2012;61(1):61-70
- CountryJapan
- Language:Japanese
-
Abstract:
Skeletal muscle is the dominant organ in locomotion and energy metabolism so that maintaining skeletal muscle function is a prerequisite for our health and independent living throughout the life. A loss or decrease in skeletal muscle function leads to increased morbidity and mortality through the development of secondary diseases such as metabolic syndrome, type 2 diabetes, obesity, cardiovascular and respiratory disease. Identifying mechanisms which influence the processes regulating skeletal muscle function is a key priority. The recent discovery of microRNAs (miRNAs) provides a new knowledge controlling skeletal muscle function. miRNAs suppress gene expression through either in inhibition of protein translation or in degradation of the mRNA transcripts through a process similar to RNA interference (RNAi). This review provides the current understanding in skeletal muscle miRNA biology and focuses on their role and regulation under physiological conditions with exercise.
