ANGIOTENSIN I CONVERTING ENZYME GENE INSERTION/DELETION POLYMORPHISM AND HUMAN PHYSICAL PERFORMANCE
- VernacularTitle:アンジオテンシン I 変換酵素遺伝子挿入/欠失多型と身体能力
- Author:
TAKURO TOBINA
;
HIROAKI TANAKA
;
YUICHIRO NISHIDA
;
AKIRA KIYONAGA
- Publication Type:Journal Article
- Keywords:
Renin-angiotensin system;
Angiotensin I converting enzyme;
Gene polymorphism;
Physical performance
- From:Japanese Journal of Physical Fitness and Sports Medicine
2008;57(5):527-532
- CountryJapan
- Language:Japanese
-
Abstract:
Angiotensin I converting enzyme (ACE) gene Insertion/Deletion (I/D) polymorphism was first shown as a genetic factor which influences human physical performance in 1998. Since then, various gene polymorphisms which influence physical performance and trainability have been reported. ACE is a key enzyme which produces angiotensin II in the renin-angiotensin system, and its activity was determined by I/D polymorphism. Many studies indicate that the I/I genotype is frequently found in elite endurance athletes, while the D/D genotype is frequently found in power-oriented elite athletes. Longitudinal studies show that the D/D genotype may contribute to enhanced strength trainability. However, it is still unclear whether the I/I genotype enhances endurance trainability. Therefore, the ACE gene I/D polymorphism can be a genetic factor which influences human physical performance.
