IMPACT OF A DIET AND EXERCISE PROGRAM FOR OBESE CHILDREN ON SERUM GHRELIN LEVELS
- VernacularTitle:肥満小児に対する食事療法と運動療法を主体とした減量が血中グレリン濃度に及ぼす影響
- Author:
YUKI KAWATA
;
KENJI TOGASHI
;
HIDENARI MASUDA
;
HIDEAKI SOYA
;
AKIRA KATSUKI
;
YOSHIHARU OSHIDA
;
YASUHIRO SUMIDA
;
MITSUMASA IGUCHI
- Publication Type:Journal Article
- Keywords:
ghrelin;
obese children;
weight reduction;
diet;
exercise
- From:Japanese Journal of Physical Fitness and Sports Medicine
2007;56(4):419-428
- CountryJapan
- Language:Japanese
-
Abstract:
Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor, has been reported to induce a GH-releasing, orexigenic effect on weight gain, and adipogenic actions. It is, therefore, thought that ghrelin links the regulatory systems for growth and energy balance.We examined 25 obese children undergoing a 3-month inpatient weight reduction program for obese children based on a combination of diet and exercise therapy and evaluated the change in the serum ghrelin levels.The subjects consisted of 25 children with moderate to severe simple obesity [17 boys, 8 girls ; mean age 9.9±1.3 years, percent overweight (% overweight) 52.1±13.6%]. Height, weight, percent body fat (% BF), fat mass, fat-free mass (FFM), and serum ghrelin were measured before and after weight reduction.After therapy, body weight, % BF and fat mass had all significantly decreased (p<0.001), while height and FFM had both significantly increased (p<0.001 ; p<0.05, respectively). There were no correlations between pre-therapy serum ghrelin and any of the following: initial height, weight, % overweight, % BF, fat mass, or FFM. However, after therapy, serum ghrelin levels were negatively correlated with body weight (rs=-0.544, p<0.01). Serum ghrelin levels increased significantly from pre- to post-therapy (113.9±30.7 to 129.6±42.9 fmol/ml, p<0.05). The rate of changes in ghrelin levels was negatively correlated with the rate of change in the % overweight (rs=-0.412, p<0.05).These findings suggest that long-term weight reduction based on a combination of diet and exercise therapy lessens the severity of obesity and increases serum ghrelin levels in obese children.
