INHIBITION OF HYPOXIC PULMONARY VASOCONSTRICTION BY HYPOXIC EXERCISE TRAINING IN RATS
- VernacularTitle:低酸素トレーニングによる低酸素性肺血管収縮の抑制
- Author:
OSAMU KASHIMURA
;
AKIO SAKAI
- Publication Type:Journal Article
- Keywords:
nitric oxide;
nitric oxide synthase inhibitor;
blood lactic acid;
perfused rat lungs
- From:Japanese Journal of Physical Fitness and Sports Medicine
2006;55(1):145-154
- CountryJapan
- Language:Japanese
-
Abstract:
This study reviewed the influence of hypoxic training on hypoxic pulmonary vasoconstriction (HPV) sensitivity in the isolated perfused lungs preparation of rats. In addition, the study examined the kind of mechanism involved. Therefore, we inhibited nitric oxide (NO) release of endothelial cells, using on NO synthase inhibitor, and reviewed the impact on HPV.As a result, the following became clear. 1)Hypoxic training inhibited HPV. 2) HPV was increased by the administration of NO synthase inhibitor L-NMMA, in particular, conspicuously inhibited HPV in the hypoxic training group was increased. 3) The negative correlation between the onset of blood lactate accumulation and HPV was significant.From the above, it can be concluded that hypoxic training inhibited HPV and NO release for a pulmonary vascular endothelial cell. In addition, we understood that HPV was decreased by hypoxic training as the ability for endurance exercise was increased.
