Successful Implantations of Autologous Peripheral Blood-Derived Mononuclear Cells Pretreated by Erythropoietin and Blood Donation in a Patient with Buerger Disease and Intractable Finger Ulcers
10.4326/jjcvs.39.29
- VernacularTitle:エリスロポエチン誘導末梢血単核球細胞移植が奏効した重症虚血性潰瘍を伴う Buerger 病の1例
- Author:
Hajime Kinoshita
;
Tamotsu Kanbara
;
Hirotsugu Kurobe
;
Tatsuo Motoki
;
Mikio Sugano
;
Homare Yoshida
;
Takashi Kitaichi
;
Masataka Sata
;
Toshio Matsumoto
;
Tetsuya Kitagawa
- Publication Type:Journal Article
- Keywords:
Buerger disease;
peripheral blood-derived;
mononuclear cell transplantation;
intractable ulcer;
CD34-positive cell
- From:Japanese Journal of Cardiovascular Surgery
2010;39(1):29-33
- CountryJapan
- Language:Japanese
-
Abstract:
A 48-year-old man with Buerger disease and intractable finger ulcers underwent successful transplantation of autologous peripheral blood-derived mononuclear cells pretreated with erythropoietin and blood donation to activate bone marrow function. Clinical symptoms on his finger ulcers improved significantly within 1 month after mononuclear cell transplantation, however, one of the intractable ulcers reappeared 2 months later. In total three transplantations were performed. Every cell transplantation revealed similar effectiveness 1 month later, and the interval of the subsequent disappearance of finger ulcers ranged from 3–6 months. There were no adverse effects based on this new therapy. These findings suggest that autologous peripheral mononuclear cell transplantation pretreated with erythropoietin and blood donation might be a non-invasive and safe alternatives for patients with Buerger disease and intractable finger ulcers.
