Marchiafava-Bignami disease with only slowly progressive cognitive impairment
10.2185/jrm.2.62
- Author:
Shuzo Shintani
;
Tatsuo Shiigai
- Publication Type:Journal Article
- MeSH:
Impaired health;
symptoms <1>;
Marchiafava-Bignami disease;
Problem drinker;
prognostic
- From:Journal of Rural Medicine
2006;2(1):62-66
- CountryJapan
- Language:Japanese
-
Abstract:
We report on a right-handed 43-year-old policeman with atypical Marchiafava-Bignami disease (MBD). The typical clinical manifestations of MBD are reduced consciousness, confusion, seizures, psychotic and emotional symptoms, hemiparesis, dysarthria, ataxia, and coma and death. However, our patient had not developed any of the above symptoms except for slowly progressive cognitive impairment mimicking that of Alzheimer disease. The incidence of MBD may be higher and its prognosis less severe than generally believed. MBD has been underdiagnosed and underreported, and nonspecific general symptoms and encephalopathy in an alcoholic might indicate undiagnosed MBD.
