Quercetin Enhances Tumorigenicity Induced by N-Ethyl-N'-Nitro-N-Nitrosoguanidine in the Duodenum of Mice*
10.1265/ehpm.6.235
- Author:
Yoshizumi MATSUKAWA
;
Hoyoku NISHINO
;
Mitsunori YOSHIDA
;
Hiroyuki SUGIHARA
;
Kanade KATSURA
;
Tetsurou TAKAMATSU
;
Junichi OKUZUMI
;
Katsuhiko MATSUMOTO
;
Fumiko SATO-NISHIMORI
;
Toshiyuki SAKAI
- Publication Type:Journal Article
- Keywords:
flavonoids;
quercetin;
mice;
duodenal tumor;
ENNG
- MeSH:
Quercetin;
Upper Case En;
ENNG;
week;
Laboratory mice
- From:Environmental Health and Preventive Medicine
2001;6(4):235-239
- CountryJapan
- Language:Japanese
-
Abstract:
Quercetin, a flavonoid, widely distributed in many fruits and vegetables, is well known to have an anti-tumor effect despite its mutagenicity. In this study, we examined the effect of dietary quercetin on duodenum-tumorigenicity of mice induced by a chemical carcinogen, N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). Eight-week-old male C57BL/6 mice were divided into 4 groups; ENNG without quercetin (group A), ENNG with 0.2% quercetin (group B), ENNG with 2% quercetin (group C), and 2% quercetin without ENNG (group D). ENNG was given in drinking water for the first 4 weeks, and thereafter quercetin was given in a mixed diet. At week 20, the average number of duodenal tumors per mouse was significantly higher in group C (mean±SE, 7.26±1.75, p<0.05) than in group A (2.32±0.31). The size of the duodenal tumors increased significantly in group B (1.79±0.09 mm, p<0.001) compared with group A (1.43±0.09 mm). In contrast, no duodenal tumor was induced in group D. The present findings suggest that excessive intake of quercetin occasionally is a risk factor for carcinogenesis of some specific organs such as the upper intestine.
