Omega-3 Fatty Acids and Cardiovascular Disease: The Epidemiological Evidence
10.1265/ehpm.6.203
- Author:
Artemis P. SIMOPOULOS
- Publication Type:Journal Article
- Keywords:
omega-3 fatty acids;
eicosapentaenoic acid;
docosahexaenoic acid;
coronary heart disease;
hypertension
- MeSH:
Fishes;
Fatty Acids, Omega-3;
Risk;
control;
Cardio-
- From:Environmental Health and Preventive Medicine
2001;6(4):203-209
- CountryJapan
- Language:Japanese
-
Abstract:
Epidemiological studies in the last 40 years suggest that omega-3 fatty acids derived from fish and fish oil decrease the risk of coronary heart disease, hypertension and stroke, and their complications. The beneficial effects of omega-3 fatty acids include effects on lipids, blood pressure, cardiac and vascular function, eicosanoids, coagulation, and immunological responses. However, not all population studies have shown that omega-3 fatty acids are associated with reduced rates of coronary mortality. Such studies suffer either from small numbers of subjects or the population already had a high intake of fish. When comparing the highest intake of fish to that of the lowest fish intake, the beneficial effects of omega-3 fatty acids have been shown. In population-based case-control studies, the patients consuming modest amounts of fish, the equivalent of one fatty fish meal per week, had a significant lower risk of primary cardiac arrest compared with those who did not eat fish at all. In case-control studies, the intake of eicosapentaenoic acid and docosahexaenoic acid as reflected in adipose tissue content is inversely associated with risk of myocardial infarction.
